Hyperargininemia

A rare autosomal recessive disorder of the urea cycle. It is caused by a deficiency of the hepatic enzyme ARGINASE. Arginine is elevated in the blood and cerebrospinal fluid, and periodic HYPERAMMONEMIA may occur. Disease onset is usually in infancy or early childhood. Clinical manifestations include seizures, microcephaly, progressive mental impairment, hypotonia, ataxia, spastic diplegia, and quadriparesis. (From Hum Genet 1993 Mar;91(1):1-5; Menkes, Textbook of Child Neurology, 5th ed, p51)

Also Known As:

Deficiency Disease, Arginase; ARG1 Deficiencies; Arginase Deficiencies; Arginase Deficiency Diseases; Deficiencies, ARG1; Deficiencies, Arginase; Deficiency Diseases, Arginase; Deficiency, ARG1; Deficiency, Arginase; Hyperargininemias; ARG1 Deficiency; Arginase Deficiency; Arginase Deficiency Disease; Argininemia

Nervous System Diseases: 14178
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Metabolic Brain Diseases: 215
      - Inborn Metabolic Brain Diseases: 2
        Inborn Urea Cycle Disorders: 569
        Hyperargininemia: 206
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Inborn Errors Metabolism: 1162
    - Inborn Metabolic Brain Diseases: 2
      - Inborn Urea Cycle Disorders: 569
        Hyperargininemia: 206
    - Inborn Errors Amino Acid Metabolism: 1
      - Inborn Urea Cycle Disorders: 569
        Hyperargininemia: 206
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Inborn Errors Metabolism: 1162
    - Inborn Metabolic Brain Diseases: 2
      - Inborn Urea Cycle Disorders: 569
        Hyperargininemia: 206
    - Inborn Errors Amino Acid Metabolism: 1
      - Inborn Urea Cycle Disorders: 569
        Hyperargininemia: 206
  - Metabolic Brain Diseases: 215
    - Inborn Metabolic Brain Diseases: 2
      - Inborn Urea Cycle Disorders: 569
        Hyperargininemia: 206

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